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Abstract

Determination of Sickle Cell Crisis in Sudanese Children with Sickle Cell Anemia

Author(s): Amged Husssien Abdelrhman, Abdegadir Ahmed

Abstract

Background: Sickle Cell Anemia (SCA) is a genetic hematological disorder characterized by red blood cells that assume an abnormal rigid, sickle shape. This hereditary disorder contributes the equivalent of 3.4% mortality in children aged under 5worldwide or 6. 4% in Africa.

Methods: Some of red blood cell profile (Hb, PCV, RBCs count and RBCs indices), WBCs count and differential count and platelet count and platelet indices and Hb eletrophoresis were determined by the automated Hematology Analyzer (SysmexBC-3000plus) and reticulocyte count was counted using supravital stain.

Results: The study was performed on diagnosed 260 children patients with sickle cell disease. Found in this study Frequency of gender among study population in female more than male and insignificant result when Comparison of age, white cells counts, red cells count, hemoglobin, Hematocrit, red cells indices, reticulocyte count and absolute Reticulocyte count among gender of sickle children. Also show insignificant result when Comparison of age, white cells counts, red cells count, hemoglobin, red cells indices, reticulocyte count and absolute Reticulocyte count among age sickle children, however it revealed a significant association with Hematocrit. Significant result show when Comparison of reticulocyte count among hemoglobin group and insignificant absolute Reticulocyte count among hemoglobin group. The Comparison of hemoglobin, reticulocyte count and absolute Reticulocyte count among WBCs. The result show Insignificant. The result were represented significant when Correlation between haemoglobin and reticulocyte count (%).

Conclusion: Insignificant result show when comparison of age, white cells counts, red cells count, hemoglobin, Hematocrit, red cells indices, reticulocyte count and absolute Reticulocyte count among gender of sickle children. The Comparison of white cells counts, red cells count, hemoglobin, red cells indices, reticulocyte count and absolute Reticulocyte count among age group result show insignificant. The Comparison of hemoglobin, reticulocyte count and absolute Reticulocyte count among WBCs. The result show insignificant and also insignificant when correlation between haemoglobin and absolute reticulocyte count. This study concluded to the significant relation between antibiotic use and Monocytes and Basophils. The study Frequency of duration of disease acute, and chronic, and The Frequency of no antibiotic use and antibiotic use. The significant relation between Eosinophils and the symptom and significant relation observed between the Eosinophils and duration of disease. The study showed insignificant correlation between platelet count and platelet indices depending on age, sex and duration of the disease. There was statistically significant Hb F, Hb S in sickle cell individuals.