Frank's Sign: Diagonal Earlobe Crease

Author(s): Tom Edward Mallinson

Given Clinical Image shows a pronounced diagonal earlobe crease (Frank’s sign) first described in 1973 [1]. Frank’s sign is strongly predictive of coronary artery disease but lacks enough specificity and sensitivity to make it pathognomonic. Frank’s Sign should be looked for as an objective marker of older age, in the same way as corneal arcus, xanthelasmata and greying hair.

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