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Psoriasis: An Overactive Wound Healing Response

Author(s): Shane Ward and Nicole Smith

The current review article focuses on "Psoriasis," a type of overactive wound healing response that affects skin and joints in 2%-3% of the general population. It is a reasonably frequent, chronic, inflammatory, and hypersensitive condition with unknown pathophysiology that affects skin and joints. Psoriasis is a skin disease caused by the immune system that begins beneath the skin's surface and causes extreme discomfort as well as negative mental health impacts. The development and prognosis of psoriasis are heavily influenced by genetic predisposition as well as environmental variables. Natural Killer (NK) cells are lymphocytes that specialise in killing virally contaminated and cancerous cells. However, evidence for a role for NK cells in psoriasis is accumulating. In psoriatic skin lesions, NK cells are detected in the inflammatory infiltrate. They can release a variety of inflammatory cytokines, many of which are involved in psoriasis aetiology. The discovery of innovative biologic medicines for the treatment of moderate to severe plaque psoriasis has resulted from the understanding of the immunopathogenesis of psoriasis. There are a slew of medicines in the works right now, with methods ranging from receptor antagonism to signal transduction system inhibition.

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