Abstract

Muse Cells in the Treatment of Skin Diseases

Author(s): Nicole Smith and Kiran Andrew

Muse cells are a subset of mesenchymal stem cells (MSCs) that express stage-specific embryonic antigen-3 (SSEA-3) and CD105. It is non-tumorigenic and may generate cells representing all three germ layers from a single cell. Muse cells can move and integrate into injured tissues that produce sphingosine-1-phosphate (S1P), and they express S1P receptor 2 selectively. Muse cell released factors have anti-inflammatory, anti-fibrosis, and anti-apoptotic properties, and they work together to complete the injured group's function and structure repair. Muse cells are described in this review as well as their basic properties and application in skin restoration.